You get to choose which gang you wage war on first, and you can mix up the missions in any way you please. Recruiting new gang members and a base of operations sees war on the three rival gangs begin. Our Player vows to return the Saints to power and sets about busting his number two Johnny Gat from Prison. The Ultor corportation led by Dean Vogel have regenerated the slums of city and the Old Saints headquarters. Things have moved on, the Saints have fell apart and three new gangs rule Stillwater. An assisted breakout sees a return to the old neighbourhood being a big disappointment. The story starts with the hero, known only as Playa, waking up in a prison hospital after being put in a coma at the end of the last game.
Everything is over the top and sometimes played completely for laughs. The characters are sterotypes lifted wholesale from American ghetto gangster culture fantasies. Saints Row 2 is a fairly bi-polar affair, it's never sure whether it wants to be an action movie, or a comedy.